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Study identifier: NCT07667322 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamics of a New Subcutaneous Formulation of Ocrelizumab in Participants With Multiple Sclerosis

Condition: Multiple Sclerosis  ·  Sponsor: Hoffmann-La Roche

PhasePhase 1
Planned participants75
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

The main purpose of this study is to evaluate the safety and tolerability of the ocrelizumab subcutaneous (SC) test formulation in participants with multiple sclerosis (MS). The study consists of two treatment phases: a dose-escalation and dose-continuation phase. Participants will receive single ascending doses of ocrelizumab SC during an initial dose-escalation phase, with the option to continue treatment with the selected dose of ocrelizumab SC in the dose-continuation phase.

This description comes directly from the study's public registry record.

Talk to the study team

Reference Study ID Number: WN45319 https://forpatients.roche.com/  ·  888-662-6728 (U.S. Only)  ·  global-roche-genentech-trials@gene.com

Always discuss trial participation with your own doctor first.

Locations (12)

Profound Research, LLCCarlsbad, California, United StatesActive Not Recruiting
Neurology Associates, PAMaitland, Florida, United StatesActive Not Recruiting
University of South FloridaTampa, Florida, United StatesActive Not Recruiting
Shepherd Center Inc.Atlanta, Georgia, United StatesActive Not Recruiting
John Hopkins University School of MedicineBaltimore, Maryland, United StatesActive Not Recruiting
Hope NeurologyKnoxville, Tennessee, United StatesActive Not Recruiting
Instituto de Neurologia de CuritibaCuritiba, Paraná, BrazilActive Not Recruiting
Centro de Pesquisas ClinicasSão Paulo, São Paulo, BrazilActive Not Recruiting
Centro de Investigacion Medico Biologico y Terapia Avanzada, S.C.Guadalajara, Jalisco, MexicoRecruiting
Inovacion y Desarrollo en ciencias de la saludMexico City, Mexico CITY (federal District), MexicoActive Not Recruiting
Nottingham University Hospitals NHS TrustNottingham, United KingdomActive Not Recruiting
Morriston HospitalSwansea, United KingdomActive Not Recruiting

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Source record: clinicaltrials.gov/study/NCT07667322