Condition: Cardiovascular Health · Functional Health · Cognitive Function Decline · Sponsor: Fundacion Miguel Servet
The increasing number of adults aged 75 years and older highlights the need for effective, low-cost interventions to preserve cardiovascular health, functional independence, and cognitive performance and to support healthy aging. Beetroot extract (BE), derived from "Beta vulgaris", contains high levels of inorganic nitrate and other bioactive compounds that may positively influence vascular and neuromuscular function. In parallel, multicomponent physical exercise is recognized as an effective strategy to improve physical and cognitive outcomes in older adults. However, evidence on the independent and combined effects of BE supplementation and structured exercise in very old adults remains limited. This randomized controlled trial is designed to evaluate the effects of BE supplementation, alone and in combination with a multicomponent physical exercise program, on blood pressure, functional performance, and cognitive function in adults aged 75 years and older. Participants will be randomly assigned to one of four groups: BE supplementation, multicomponent exercise, combined BE supplementation and exercise, or a control condition, over a predefined intervention period. The exercise program will include strength, balance, mobility, and aerobic components specifically adapted to the abilities and safety requirements of old adults. The primary outcomes of the study will assess changes in cardiovascular health, physical and functional performance, and cognitive function using sta…
This description comes directly from the study's public registry record.
Nicolas Martinez-Velilla, Md-PhD · 00 34 848422222 · nicolas.martinez.velilla@navarrra.es
Fabricio Zambom-Ferraresi, PhD · 00 34 848422222 · fabricio.zambom.ferraresi@navarra.es
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| Hospital Universitario de Navarra | Pamplona, Navarre, Spain | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07666685