Condition: Therapy · Pleural Infections · Sponsor: Centre Hospitalier Universitaire, Amiens
Intrapleural enzyme therapy (IET) is regarded by recent guidelines as a "rescue" therapy for managing complicated pleural infections; however, it is associated with significant side effects, including pleural bleeding, pain, and fever. Pleural irrigation with saline may serve as an alternative, yet evidence supporting its effectiveness is limited to a single small- scale, single-center randomized trial. The objective of the study is to compare the risk of treatment failure at 30 days (defined as a composite outcome that includes death, the need for thoracic surgery, or additional intrapleural enzyme therapy) between an early pleural irrigation strategy and standard care for complicated pleural infections.
This description comes directly from the study's public registry record.
Damien BASILLE, Pr · 33+3 22 45 59 10 · basille.damien@chu-amiens.fr
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| CHU Amiens Picardie | Amiens, Picardie, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07666464