Condition: Ovarian Cancer · HGSOC · HGS Ovarian, Fallopian Tube or Primary Peritoneal Cancer · Sponsor: Epitopea Ltd
Ovarian, fallopian tube, or primary peritoneal cancer, collectively referred to as ovarian cancer, remains the deadliest type of gynaecological cancer. The most common and aggressive form is called high-grade serous ovarian cancer. The main purpose of this study is to understand whether an experimental study vaccine, CryptiVax-1001, is safe when administered to patients with high-grade serous ovarian cancer (HGSOC). The study vaccine is a cancer vaccine, which aims to delay or possibly prevent the cancer from coming back. However, as this is the first study of the vaccine in patients, the primary purpose of this study is to assess the safety of the study vaccine. Following surgery and platinum-based chemotherapy participants may enter the trial and receive CryptiVax-1001 as an explorative maintenance therapy. The main purposes of this study are therefore to: * assess how well the study vaccine is tolerated and identify any side effects. * analyse the study vaccine's capacity to activate your immune system The study will test escalating dose levels of CryptiVax-1001 based on the safety evaluations to estimate appropriate future dose levels for CryptiVax-1001.
This description comes directly from the study's public registry record.
Head of Development Operations · +4530660105 · Gertrud.Rasmussen@epitopea.com
Head of Oncology Development · +4795113393 · Siri.Torhaug@Epitopea.com
Always discuss trial participation with your own doctor first.
| Cambridge University Hospitals NHS Foundation Trust - Addenbrookes Hospital | Cambridge, United Kingdom | Recruiting |
| The University of Edinburgh - Western General Hospital - Edinburgh Cancer Research Centre | Edinburgh, United Kingdom | Not Yet Recruiting |
| Beatson West of Scotland Cancer Centre | Glasgow, United Kingdom | Not Yet Recruiting |
| St. James's University Hospital | Leeds, United Kingdom | Recruiting |
| University Hospitals of Leicester NHS Trust -Leicester Royal Infirmary | Leicester, United Kingdom | Recruiting |
| University College London Hospitals NHS Foundation Trust - Cancer Clinical Trials Unit | London, United Kingdom | Recruiting |
| Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital | London, United Kingdom | Not Yet Recruiting |
| Royal Marsden NHS Foundation Trust - Royal Marsden Hospital | London, United Kingdom | Recruiting |
| Lancashire Teaching Hospitals NHS Foundation Trust - Royal Preston Hospital | Preston, United Kingdom | Not Yet Recruiting |
| Royal Marsden NHS Foundation Trust - Institute of Cancer Research | Sutton, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07665515