Condition: Cirrhotic Cardiomyopathy · Sponsor: Vanderbilt University Medical Center
Cirrhotic Cardiomyopathy (CCM) is a recognized complication of cirrhosis, but understudied despite recent retrospective data suggesting it may be common, affecting one in three patients with decompensated cirrhosis, and associated with significantly increased risk of death and adverse hepatic and cardiac events. Moreover, evidence from preclinical models and children suggest elevated bile acids in the blood may contribute to CCM, but data from adults with cirrhosis are scarce. Therefore, this study will be the first contemporary prospective multicenter investigation of CCM in adults with cirrhosis in the United States. The study will characterize risk factors for CCM, determine its impact on clinical outcomes, and investigate the contribution of circulating bile acids to disease development.
This description comes directly from the study's public registry record.
Manhal Izzy, MD · 615-875-6540 · manhal.izzy@vumc.org
Deepak Gupta, MD · d.gupta@vumc.org
Always discuss trial participation with your own doctor first.
| Vanderbilt University Medical Center | Nashville, Tennessee, United States | Recruiting |
| UT Southwestern Medical Center | Dallas, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07658222