Condition: Severe Asthma · Asthma · Sponsor: Helsinki University Central Hospital
Physical activity has been shown to improve asthma control in individuals with asthma. Patients with severe asthma frequently experience exacerbations, which often result in a physically inactive lifestyle. The investigators therefore hypothesize that patients with severe asthma who initiate biological therapy may particularly benefit from increased physical activity, both in terms of exercise capacity and asthma control. The aim of this study is to determine whether an individually tailored exercise program improves exercise capacity and asthma control in patients with severe asthma. Additionally, the study evaluates the effects of the intervention on asthma symptoms, frequency of exacerbations, lung function, quality of life, and body composition. The primary outcome is the change in exercise tolerance, measured as peak oxygen uptake during cardiopulmonary exercise testing. Secondary outcomes include asthma symptoms (proportion of patients reporting improvement based on the Asthma Control Test), frequency of exacerbations, changes in lung function (FVC and FEV1), asthma-related quality of life (AQLQ), and changes in body composition (body mass index and waist circumference). At baseline, all participants undergo fitness assessments, including cardiopulmonary exercise testing and muscle strength tests. Participants are then randomized into two groups. The intervention group receives an individually tailored 6-month exercise program designed by a sports medicine physician…
This description comes directly from the study's public registry record.
Hanna Hisinger-Mölkänen, MD, PhD · +358 40 6654484 · hanna.hisinger-molkanen@hus.fi
Annina Lyly, MD, PhD · +358 50 4287952 · annina.lyly@hus.fi
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| Helsinki University Hospital | Helsinki, Finland | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07655037