Condition: Fluid Responsiveness Predictability in Sepsis · Sponsor: Pakistan Institute of Medical Sciences
The goal of this clinical trial is to determine whether common carotid artery blood flow measured by bedside Doppler ultrasound can accurately identify fluid responsiveness in mechanically ventilated adults with sepsis. The study will compare this method with transthoracic echocardiography-derived cardiac output, which is a commonly used non-invasive technique for assessing hemodynamic status in critically ill patients. The study also aims to evaluate whether carotid artery ultrasound can provide a faster and more practical bedside assessment during fluid resuscitation in the intensive care unit. In patients with sepsis, giving too little intravenous fluid may worsen organ perfusion and shock, while excessive fluid administration may lead to complications such as pulmonary edema, worsening oxygenation, prolonged mechanical ventilation, and longer intensive care unit stay. Because of this, clinicians need reliable methods to identify which patients are likely to benefit from fluid administration. This concept is known as fluid responsiveness. The main questions this study aims to answer are: * Can common carotid artery blood flow measured by ultrasound predict fluid responsiveness as accurately as transthoracic echocardiography-derived cardiac output? * How closely do changes in carotid artery blood flow correspond to changes in cardiac output during passive leg raising? * Can carotid ultrasound provide a quicker and simpler bedside method for assessing fluid responsiveness…
This description comes directly from the study's public registry record.
Sana Zulfiqar, MBBS · +923335329538 · sanazulfiqar53@gmail.com
Syed Muneeb Ali, MBBS, MCCM, MD CCM · +923335329538 · Syed.muneeb.ali@gmail.com
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| Pakistan Institute Of Medical Sciences | Islamabad, Federal Area, Pakistan | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07653568