Condition: Hormone Receptor Positive Breast Cancer · Sponsor: Tel-Aviv Sourasky Medical Center
This phase II, open-label, single-arm, study investigates the clinical benefit of everolimus combined with endocrine therapy (ET) in hormone receptor-positive (HR+), metastatic breast cancer (MBC) patients who progressed on prior PI3K inhibitor therapy (+ ET). The trial aims to determine if sequential inhibition of the PI3K/AKT/mTORC1 pathway retains efficacy post-PI3K inhibitor resistance, hypothesizing that everolimus will demonstrate a response rate exceeding the historical 9.5% observed in the BOLERO2 trial.
This description comes directly from the study's public registry record.
Breast Cancer coordinator Breast Cancer coordinator · 972-03-6974092 · hananm@tlvmc.gov.il
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| Ichilov-Sourasky Medical Center | Tel Aviv, Israel | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07646171