Condition: Acute Kidney Injury · Fluid Overload · Fluid Overload in Dialysis Patients · Sponsor: Hospital Las Higueras
Acute kidney injury (AKI) is common in critically ill patients and is frequently associated with fluid overload, which can worsen clinical outcomes. Continuous renal replacement therapy (CRRT) allows fluid removal through net ultrafiltration (UFNET), but some patients develop hemodynamic instability or signs of poor tissue perfusion during this process. The purpose of this prospective observational study is to evaluate tolerance to net ultrafiltration in critically ill patients with AKI receiving CRRT. The study will assess clinical, hemodynamic, ultrasound, perfusion, and biochemical parameters before and during fluid removal to identify factors associated with ultrafiltration intolerance. The investigators hypothesize that alterations in hemodynamic, perfusion, and congestion-related parameters can identify patients at increased risk of ultrafiltration intolerance before the development of overt hypotension. The results may help improve individualized fluid removal strategies and optimize the safety of CRRT in critically ill patients.
This description comes directly from the study's public registry record.
Gonzalo Ramírez-Guerrero, MD · +56981746173 · ramirezguerrero.g@gmail.com
Cristian Pedreros-Rosales, MD · cpedreros@me.com
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| Hospital Clínico Regional de Concepción | Concepción, Chile | Not Yet Recruiting |
| Complejo Asistencial Dr. Victor Ríos Ruiz | Los Ángeles, Chile | Not Yet Recruiting |
| Hospital Clínico Dra. Eloísa Díaz Insunza de La Florida | Santiago, Chile | Not Yet Recruiting |
| Hospital Las Higueras de Talcahuano | Talcahuano, Chile | Recruiting |
| Hospital Universitario San José de Popayán | Popayán, Colombia | Recruiting |
| Hospital General Enrique Garces | Quito, Ecuador | Not Yet Recruiting |
| Ospedale San Bortolo | Vicenza, Italy | Not Yet Recruiting |
| Hospital General de Mexico | Mexico City, Mexico | Recruiting |
| Hospital Nacional Cayetano Heredia | Lima, Peru | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07643597