Condition: ER-positive, HER2-negative Breast Cancer · Breast Cancer Stage I · Breast Cancer Stage II · Sponsor: University Health Network, Toronto
This is a Phase 2 study for patients with resected Stage I-III HR+/HER2-negative breast cancer with detected molecular residual disease (MRD+) following standard neo/adjuvant and locoregional therapy delivered with curative intent. In this study participants will be treated with capecitabine. Capecitabine will be administered orally at a dose of 500 mg 3 times daily for up to 12 months, or until the time of clinical recurrence, discontinuation due to toxicity, or withdrawal of consent. This study will have two stages, stage 1 would enroll up to 8 participants to clear the Minimal Residual Disease (MRD) and Stage 2 will enroll up to 5 participants. The purpose of this study is to determine if this study population would have a better outcome from receiving capecitabine rather than having no change in treatment if MRD is detected.
This description comes directly from the study's public registry record.
David Cescon, MD · 416-946-2245 · dave.cescon@uhn.ca
Always discuss trial participation with your own doctor first.
| UHN - Princess Margaret Cancer Centre | Toronto, Ontario, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07631052