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Study identifier: NCT07629960 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations

Condition: Advanced Solid Tumor · Non-Small Cell Lung Cancer · Colorectal Neoplasms  ·  Sponsor: Blueprint Medicines Corporation

PhasePhase 1/Phase 2
Planned participants265
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

A first in human study to evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of BLU-924 / SAR449336, a pan-KRAS inhibitor, in participants with advanced Pancreatic Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer harboring KRAS mutations.

This description comes directly from the study's public registry record.

Talk to the study team

Blueprint Medicines  ·  1-888-258-7768  ·  medinfo@blueprintmedicines.com

Always discuss trial participation with your own doctor first.

Locations (1)

Next Oncology Virginia Cancer SpecialistFairfax, Virginia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07629960