Condition: Feasibility Study · Vaccine Immune Response · Rota Virus Gastroenteritis · Sponsor: Centre for Infectious Disease Research in Zambia
The Rotavirus SpatioTrasncriptomics (Rota-Omics) study is a multidisciplinary research project aimed at understanding why oral rotavirus vaccines perform less effectively in some low- and middle-income countries, including Zambia. Rotavirus remains one of the leading causes of severe diarrheal disease in infants and young children worldwide, despite the widespread introduction of vaccines such as Rotarix® and Rotavac®. Although these vaccines have greatly reduced childhood deaths in many countries, vaccine effectiveness is often lower in settings where the burden of disease is highest. Understanding the reasons behind this reduced protection is critical for improving child health globally. A major focus of the study is Environmental Enteropathy (EE), also known as Environmental Enteric Dysfunction (EED), a chronic inflammatory condition of the small intestine that is common in low-resource settings. EE is associated with damage to the intestinal lining, chronic immune activation, poor nutrient absorption, and impaired gut barrier function. These changes are thought to interfere with the body's ability to respond effectively to oral vaccines, which rely on strong intestinal immune responses. The RotaOmics study uses a systems biology approach to investigate how the immune system, gut microbiome, nutrition, and intestinal inflammation interact to influence rotavirus vaccine responses. The term "omics" refers to advanced technologies that allow researchers to study genes, prot…
This description comes directly from the study's public registry record.
Michelo Simuyandi, Post Graduate (MSc) · +260968424794 · michelo.simuyandi@cidrz.org
Stanley Mwale, Master's Degree (MPH) · +260966745554 · stanley.mwale@cidrz.org
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| TROPGAN | Lusaka, Lusaka Province, Zambia | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07626606