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Study identifier: NCT07621718 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 )

Condition: Pancreatic Cancer · Pancreatic Cancer Metastatic · PDAC  ·  Sponsor: Revolution Medicines, Inc.

PhasePhase 3
Planned participants670
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the efficacy of an investigational RAS(ON) inhibitor administered in combination with chemotherapy compared to placebo in combination with chemotherapy.

This description comes directly from the study's public registry record.

Talk to the study team

Revolution Medicines Study Director  ·  1-844-2-REVMED  ·  medinfo@revmed.com

Always discuss trial participation with your own doctor first.

Locations (4)

Moffitt Cancer CenterTampa, Florida, United StatesRecruiting
Piedmont HealthcareAtlanta, Georgia, United StatesRecruiting
University of Chicago Medical CenterChicago, Illinois, United StatesRecruiting
Johns Hopkins UniversityBaltimore, Maryland, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07621718