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Study identifier: NCT07621237 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

Condition: Major Depressive Episode (MDE) · Major Depressive Disorder (MDD) · Depression  ·  Sponsor: Tonix Pharmaceuticals, Inc.

PhasePhase 2
Planned participants360
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn if a drug called TNX-102 SL works to treat moderate to severe major depressive disorder in adults. It will also learn about the safety of TNX-102 SL. The main questions it aims to answer are: Does TNX-102 SL improve depression symptoms according to a depression symptom rating scale? What medical problems do participants have when taking TNX-102 SL? Researchers will compare TNX-102 SL to a placebo (a look-alike substance that contains no drug) to see if TNX-102 SL works to treat major depressive disorder. Participants will: Take TNX-102 SL or a placebo every night at bedtime for 6 weeks Visit the clinic once every 2 weeks for checkups and tests

This description comes directly from the study's public registry record.

Talk to the study team

Timothy Roush  ·  (862) 799-8599  ·  timothy.roush@tonixpharma.com

Always discuss trial participation with your own doctor first.

Locations (25)

IMA Clinical Research- PhoenixPhoenix, Arizona, United StatesNot Yet Recruiting
Inland Psychiatric Medical Group, Inc. - ChinoChino, California, United StatesNot Yet Recruiting
Synergy Research - San DiegoLemon Grove, California, United StatesNot Yet Recruiting
Nrc Research InstituteOrange, California, United StatesNot Yet Recruiting
Artemis Institute For Clinical Research - San DiegoSan Diego, California, United StatesNot Yet Recruiting
Sunwise Clinical Research, LlcWalnut Creek, California, United StatesNot Yet Recruiting
Clinical Neuroscience Solutions Inc. - JacksonvilleJacksonville, Florida, United StatesNot Yet Recruiting
K2 Medical Research - MaitlandMaitland, Florida, United StatesNot Yet Recruiting
Central Miami Medical Institute Llc.Miami, Florida, United StatesNot Yet Recruiting
Medical Research Group of Central FloridaOrange City, Florida, United StatesNot Yet Recruiting
Clinical Neuroscience Solutions Inc. - OrlandoOrlando, Florida, United StatesRecruiting
K2 Medical Research - TampaTampa, Florida, United StatesNot Yet Recruiting

+ 13 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07621237