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Study identifier: NCT07619144 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

OPTIMIZE 5.5 - Optimizing Impella 5.5 Outcomes Through Advanced Data Science

Condition: Cardiogenic Shock · Mechanical Circulatory Support · Cardiogenic Shock Post Myocardial Infarction  ·  Sponsor: Medical University of Vienna

PhaseN/A
Planned participants100
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The main goal of this observational, study is to develop a clinical decision support tool utilizing Impella 5.5 pump parameters to predict native heart recovery and prevent adverse events, by leveraging data science and real-world clinical data of cardiogenic shock patients. Therefore, secondary objectives are essential to consolidating a retrospective longitudinal analysis of Impella 5.5 pump data alongside ICU digital health record datasets to: 1. Validate the Impella 5.5 placement signal by comparing it with ICU arterial line waveforms. 2. Integrate pump data with ICU clinical data to identify patterns associated with therapy outcomes, including native heart recovery, heart replacement therapy, and mortality while on device support. 3. Define clinical scenarios linked to hemolysis, HRAEs, and arrhythmias and develop predictive models to mitigate their occurrence.

This description comes directly from the study's public registry record.

Talk to the study team

Thomas Schlöglhofer, PhD, MSc  ·  +4314040027280  ·  thomas.schloeglhofer@meduniwien.ac.at

Lukas Ruoff, MSc  ·  lukas.ruoff@meduniwien.ac.at

Always discuss trial participation with your own doctor first.

Locations (1)

Medical University of ViennaVienna, AustriaRecruiting

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Source record: clinicaltrials.gov/study/NCT07619144