Condition: Metastatic Colorectal Cancer · BRAF V600E Mutation · Sponsor: Swiss Cancer Institute
This study prospectively investigates the molecular mechanisms of primary and acquired resistance to standard-of-care BRAF V600E-directed therapy in patients with metastatic colorectal cancer and aims to pre-clinically develop novel strategies to reverse therapy resistance. Clinically approved combination treatment with cetuximab, encorafenib and chemotherapy improves patient outcomes, yet patients eventually experience disease progression. In this prospective multicenter study, tumor tissue, blood, and stool samples will be collected before treatment and at progression, to identify genetic and non-genetic mechanisms of resistance. Additionally, tumor tissue-based in vitro models (patient-derived organoids, PDOs) will be generated and exploited for functional in vitro testing, including genomic and pharmacologic perturbation studies. The overarching goal is to generate knowledge that can help develop new and more effective treatment strategies for future patients.
This description comes directly from the study's public registry record.
Krista Zackel · +41313899191 · trials@swisscancerinstitute.ch
Always discuss trial participation with your own doctor first.
| Kantonsspital Aarau | Aarau, Switzerland | Recruiting |
| Kantonsspital Baden | Baden, Switzerland | Recruiting |
| St. Claraspital | Basel, Switzerland | Recruiting |
| Universitaetsspital Basel | Basel, Switzerland | Recruiting |
| Inselspital Bern | Bern, Switzerland | Recruiting |
| Spitalzentrum Biel - MEDIN La Tour | Biel, Switzerland | Recruiting |
| Kantonsspital Graubünden | Chur, Switzerland | Recruiting |
| Luzerner Kantonsspital | Lucerne, Switzerland | Recruiting |
| HOCH Health Ostschweiz - Kantonsspital St. Gallen | Sankt Gallen, Switzerland | Recruiting |
| Bürgerspital Solothurn | Solothurn, Switzerland | Recruiting |
| HFR Freiburg - Kantonsspital | Villars-sur-Glâne, Switzerland | Recruiting |
| Kantonsspital Winterthur | Winterthur, Switzerland | Recruiting |
+ 1 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07617610