Condition: Osteoporosis · Menopause · Sponsor: Istituto Auxologico Italiano
Osteoporosis is a systemic skeletal disorder affecting approximately 10% of individuals over 50 years of age. It is characterised by an increased risk of fragility fractures, which constitute a major source of morbidity, mortality, and healthcare burden worldwide. A range of pharmacological therapies has been approved for osteoporosis, with demonstrated efficacy in reducing fracture risk. These include anabolic agents that stimulate osteoblast-mediated bone formation (teriparatide, abaloparatide), antiresorptive agents that inhibit osteoclast-driven bone resorption (bisphosphonates, denosumab), and dual-action agents such as romosozumab, which, through sclerostin inhibition, simultaneously enhances bone formation and suppresses resorption. In clinical practice, these agents are administered sequentially or in combination to optimise therapeutic outcomes. The primary goal of anti-osteoporotic therapy is to reduce the risk of incident and subsequent fractures. In postmenopausal osteoporosis, this objective is closely linked to meaningful gains in bone mineral density (BMD), as measured by dual-energy X-ray absorptiometry (DEXA), with attainment of osteopenic ranges associated with low fracture probability (\<15% for major osteoporotic fractures and \<3% for hip fractures, according to FRAX). However, selecting the most effective therapeutic strategy remains challenging, as robust predictors of individual treatment response are lacking. Although bone turnover markers are widel…
This description comes directly from the study's public registry record.
Sabrina Corbetta, Prof. · +3902619111 · s.corbetta@auxologico.it
Luca Grappiolo, Dr. · +3902619111 · luca.grappiolo@auxologico.it
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| Istituto Auxologico Italiano IRCCS | Miano, Lombardy, Italy | Recruiting |
| IRCCS Ospedale Galeazzi Sant'Ambrogio | Milan, Lombardy, Italy | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07616401