Condition: Ovarian Cancer · Squamous Non-Small Cell Lung Cancer (NSCLC) · Synovial Sarcomas · Sponsor: Zelluna Immunotherapy AS
This study will recruit patients with the following cancer indications: ovarian cancer, squamous non-small cell lung cancer, synovial sarcoma and head and neck cancer, with inoperable locally advanced or metastatic solid tumours. Currently, these patients have a poor prognosis and a relatively short overall survival. There is a lack of meaningful, effective therapies available that improve the outcome for these patients. The treatment being investigated in this study is ZIMA4-1, an allogeneic cell therapy product. This is the first time ZI-MA4-1 will be administered to humans. The study is planned to consist of two parts (A and B). Part A includes up to four dose escalation cohorts and aims to identify the maximum tolerated dose of ZI-MA4-1 and give insight into the recommended Phase 2 dose (RP2D). Part B consists of an expansion cohort and is designed to further evaluate the RP2D identified in Part A across one or more indications. The study procedures and eligibility criteria will be the same for participants in Parts A and B, except for the dose level of ZI-MA4-1.
This description comes directly from the study's public registry record.
Zelluna Immunotherapy · +47 413 80 080 · ctinfo@zelluna.com
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| The Royal Marsden NHS Foundation Trust | London, United Kingdom | Not Yet Recruiting |
| The Christie NHS Foundation Trust | Manchester, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07613723