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Study identifier: NCT07613294 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk

Condition: Atherosclerosis · Cardiovascular Diseases · Lipoprotein(a)  ·  Sponsor: Eli Lilly and Company

PhasePhase 3
Planned participants252
Who can joinAll sexes, 45 Years to 80 Years
Healthy volunteersNo

About this study

Lipoprotein(a), also known as Lp(a), is a protein that carries cholesterol and proteins in your blood. People with high Lp(a) have a higher risk for heart disease. The main purpose of the study is to investigate how lepodisiran, compared to a placebo, affects the amount and type of plaque in the heart's vessels using an imaging technology known as Coronary Computed Tomography Angiography (CCTA) in adults who have high levels of Lp(a). Participation will last about 120 weeks.

This description comes directly from the study's public registry record.

Talk to the study team

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or  ·  317-615-4559  ·  LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact  ·  clinical_inquiry_hub@lilly.com

Always discuss trial participation with your own doctor first.

Locations (58)

UCSD - Altman Clinical and Translational Research Institute (ACTRI)La Jolla, California, United StatesNot Yet Recruiting
Valley Clinical Trials, Inc.Northridge, California, United StatesRecruiting
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterTorrance, California, United StatesNot Yet Recruiting
Jellinger and Lerman, MD PA dba The Center for Diabetes and Endocrine CareFort Lauderdale, Florida, United StatesRecruiting
Jacksonville Center for Clinical ResearchJacksonville, Florida, United StatesNot Yet Recruiting
Merritt Island Medical Research, LLCMerritt Island, Florida, United StatesRecruiting
Inpatient Research ClinicMiami Lakes, Florida, United StatesNot Yet Recruiting
Clinical Site Partners, LLC dba Flourish ResearchWinter Park, Florida, United StatesRecruiting
CARE Institute - High DesertMeridian, Idaho, United StatesNot Yet Recruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesNot Yet Recruiting
Profound Research LLCFarmington Hills, Michigan, United StatesRecruiting
Vector Clinical TrialsLas Vegas, Nevada, United StatesRecruiting

+ 46 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07613294