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Study identifier: NCT07612774 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

CAPRA-EVO: a Randomized Serial PCCT Trial of Early Evolocumab After ACS

Condition: Coronary · Coronary Artery Disease  ·  Sponsor: West China Hospital

PhasePhase 4
Planned participants233
Who can joinAll sexes, 40 Years to 75 Years
Healthy volunteersNo

About this study

The CAPRA-EVO trial is a single-center, randomized, open-label study with blinded endpoint assessment comparing early evolocumab plus standard lipid-lowering therapy versus standard-of-care lipid-lowering therapy in patients with acute coronary syndrome after successful percutaneous coronary intervention. The study will use serial photon-counting coronary computed tomography angiography at baseline and 52 weeks to assess changes in non-culprit coronary plaque burden and stenosis severity. Secondary outcomes include changes in high-risk plaque features, lipid and inflammatory biomarkers, cardiovascular events, and safety outcomes. The trial aims to determine whether early intensive LDL-C lowering with evolocumab can reduce coronary plaque progression and support PCCT-CCTA as a noninvasive tool for monitoring atherosclerotic plaque dynamics.

This description comes directly from the study's public registry record.

Talk to the study team

Xiaoyu Wang  ·  86+18384252874  ·  wxy2cd@yeah.net

Always discuss trial participation with your own doctor first.

Locations (1)

West China Hospital of Sichuan UniversityChengdu, Sichuan, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT07612774