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Study identifier: NCT07606807 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

rhTNK-tPA for Acute Ischemic Stroke Under Simplified Imaging in the Extended Time Window

Condition: Acute Ischemic Stroke  ·  Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

PhasePhase 3
Planned participants750
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The PEARL-SIMPLIFIED trial is a multicenter, prospective, randomized controlled, open-label, blinded-endpoint study. It aims to evaluate the efficacy and safety of intravenous tenecteplase (TNK) in patients with acute ischemic stroke (AIS) presenting in the extended 4.5-24 hour window, using a simplified imaging selection strategy based solely on non-contrast CT (NCCT).

This description comes directly from the study's public registry record.

Talk to the study team

Jinyuan Wang  ·  86-18558992193  ·  wangjy257@mail2.sysu.edu.cn

Xinguang Yang, MD, PhD  ·  yangxinguang0926@163.com

Always discuss trial participation with your own doctor first.

Locations (1)

Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityGuangzhou, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT07606807