Condition: Patients With Drug-resistant Focal Epilepsy · SEEG as Part of Presurgical Evaluation · Sponsor: Hospices Civils de Lyon
Interactions between epilepsy and sleep are numerous and bidirectional. Sleep can facilitate epileptic activity and seizures in several syndromes, while sleep deprivation increases cortical excitability and seizure susceptibility. Conversely, sleep disturbances are highly prevalent in patients with epilepsy (PWE). Using simultaneous stereoelectroencephalography (SEEG)-polysomnography, the investigators previously showed that sleep fragmentation in focal drug-resistant epilepsy is associated with both ictal and interictal epileptic activity, with increased interictal epileptiform discharges (IED) immediately before and during arousals. However, causality remains unclear, as sleep instability itself may promote epileptic discharges. Determining whether nocturnal seizures and IED directly induce awakenings is clinically important. Nocturnal epileptic activity is often considered less disabling than daytime seizures and rarely guides treatment decisions, yet demonstrating a direct impact on sleep continuity could support therapeutic strategies specifically targeting nocturnal epileptic activity to improve sleep quality. Beyond sleep continuity, epilepsy may also influence cognitive processes during sleep, including subjective sleep depth and dreaming. While the cognitive consequences of epilepsy during wakefulness are well established, relationships between epileptic activity, sleep architecture and subjective sleep experiences remain poorly understood. In a survey of 300 PWE, …
This description comes directly from the study's public registry record.
PETER-DEREX MD Laure, MD · +33 (0) 4 72 35 70 44 · laure.peter-derex@chu-lyon.fr
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| Epilepsy Department, Duke University Hospital | Durham, North Carolina, United States | Not Yet Recruiting |
| Service de Neurologie Fonctionnelle et d'Epileptologie Hôpital Neurologique, GHE, Hospices Civils de Lyon Hôpital Neurologique Pierre WERTHEIMER | Bron, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07605858