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Study identifier: NCT07604272 Synced from ClinicalTrials.gov · July 28, 2026
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Reversing InGuinal Hernia Trial: The Evaluation of Sex Hormones to Reverse Inguinal Hernias in Males

Condition: Inguinal Hernia Unilateral · Inguinal Hernia Bilateral · Inguinal Hernia Without Obstruction or Gangrene  ·  Sponsor: Northwestern University

PhasePhase 1
Planned participants30
Who can joinMale, 50 Years to no upper limit
Healthy volunteersNo

About this study

This is a prospective, single-center, three-arm Phase 1 safety and feasibility trial evaluating anti-estrogen therapy in men age 50 years and older with symptomatic unilateral inguinal hernias. Participants will be randomized to receive fulvestrant 250 mg intramuscularly, fulvestrant 500 mg intramuscularly, or letrozole 5 mg orally for 6 months. The study will evaluate safety, tolerability, feasibility, hormone changes, hernia size, patient-reported outcomes, bone density, and imaging-based hernia classification.

This description comes directly from the study's public registry record.

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Locations (1)

Northwestern Memorial HospitalChicago, Illinois, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07604272