Condition: ARDS (Acute Respiratory Distress Syndrome) · Sponsor: Hospital Dr. Franco Ravera Zunino
Acute Respiratory Distress Syndrome (ARDS) is characterized by severe hypoxemia and diffuse alveolar collapse, often requiring invasive mechanical ventilation. Non-individualized mechanical ventilation settings can cause ventilator-induced lung injury (VILI). Positive end-expiratory pressure (PEEP) prevents alveolar collapse, but its effect varies among individuals. The recruitment-to-inflation (R/I) ratio evaluates bedside lung recruitment potential. This pilot study aims to compare two individualized PEEP titration strategies-one guided by the best static respiratory compliance and another guided by transpulmonary pressure via an esophageal balloon-and evaluate how baseline lung recruitment potential alters the early physiological responses to these interventions. Both strategies are preceded by an identical, standardized pressure-controlled initial lung recruitment maneuver to establish a baseline recruitment state.
This description comes directly from the study's public registry record.
Esteban Santis, RT. · 940367716 · esteban.santis@ogb.cl
Hospital Dr. Franco Ravera Zunino · 729383 · carolina.lindsay.brain@gmail.com
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| Dr. Franco Ravera Zunino Hospital | Rancagua, Región del Libertador General Bernardo O’Higgins, Chile | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07603310