Condition: Cholangiocarcinoma · Colorectal Cancer · Non-Small Cell Lung Cancer · Sponsor: University of Pennsylvania
This is a Phase I, open-label dose finding study to assess the safety, manufacturing feasibility, and preliminary efficacy of TCR1188-ABC cells in patients with KRAS-mutated cancers. Initially, patients with KRAS G12V mutation positive metastatic pancreatic adenocarcinoma, cholangiocarcinoma, colorectal cancer, or non-small cell lung cancer (NSCLC) will be targeted for participation. Up to 4 total dose levels will be evaluated using a 3+3 dose escalation design.
This description comes directly from the study's public registry record.
Abramson Cancer Center Clinical Trials Service · 215-349-8245 · PMCancerResearch@pennmedicine.upenn.edu
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| University of Pennsylvania | Philadelphia, Pennsylvania, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07594067