Condition: Emotional Processing and Cognitive Function in Perimenopausal Women Experiencing Cognitive Perturbations · Perimenopause · Perimenopause-Related Depression · Sponsor: University of Oxford
Recent evidence suggests multi-strain probiotics containing Lactobacillus rhamnosus and Bifidobacterium longum have been found to enhance emotional processing and reduce salience to negative cues in studies involving people with mood disorders, as well as improve cognitive functions, such as memory and concentration, in healthy participants. By administering computer-based tasks, questionnaires and checking biological measures (cortisol, immune markers, blood metabolites, gut microbiota) using blood and faecal samples, this experimental medicine study aims to investigate whether a probiotic supplement has an effect on emotional processing and cognition in perimenopausal women. We also aim to study changes in gut bacteria from stool samples before and after taking the supplement to see if any microbiome changes are associated with any effects in emotional processing, cognitive function, and biological markers.
This description comes directly from the study's public registry record.
Phil Burnet, Professor · +44 1865 618327 · phil.burnet@psych.ox.ac.uk
Susannah Murphy, Professor · +44 1865 618313 · susannah.murphy@psych.ox.ac.uk
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| University of Oxford, Department of Psychiatry | Oxford, England, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07590999