Condition: MDS (Myelodysplastic Syndrome) · AML (Acute Myeloid Leukemia) · Sponsor: Fujian Medical University Union Hospital
This study aims to investigate the clinical efficacy of haploidentical-cord blood hematopoietic stem cell transplantation in patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (MDS), and to analyze the impact of different engraftment patterns (haploidentical engraftment versus cord blood engraftment) on clinical outcomes. By comparing the efficacy of haploidentical-cord blood transplantation in different subtypes of AML and MDS, this research will explore its unique advantages and comparative effectiveness relative to conventional transplantation strategies, so as to provide new evidence for clinical practice. Specific research objectives I. To evaluate the efficacy of haploidentical-cord blood hematopoietic stem cell transplantation for AML and high-risk MDS, including the speed of hematopoietic recovery, immune tolerance, and long-term survival rates. II. To compare the effects of different engraftment patterns (haploidentical engraftment vs. cord blood engraftment) on quality of life, immune tolerance, early complications, and long-term prognosis. III. To identify the clinical advantages and indications of haploidentical-cord blood transplantation through data analysis, and to provide a theoretical basis for clinical decision-making. Novelty of the Study I. Innovation in Hematopoietic Stem Cell Infusion Schedule The present study employs a sequential infusion strategy: haploidentical stem cells are infused on Day 0, and umbilical cord bl…
This description comes directly from the study's public registry record.
Nainong Li, MD · +86 13365910189 · nainli@aliyun.com
Lihua Wu, MD · +86 18359180265 · 877998423@qq.com
Always discuss trial participation with your own doctor first.
| Fujian Medical University Union Hospital | Fuzhou, Fujian, China | Recruiting |
| Guangdong Provincial People's Hospital | Guangzhou, Guangdong, China | Not Yet Recruiting |
| Sichuan Provincial People's Hospital | Chengdu, Sichuan, China | Not Yet Recruiting |
| Chinese PLA General Hospital | Beijing, China | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07588360