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Study identifier: NCT07584434 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Phase 1, First-in-human Study of VX-433

Condition: Narcolepsy Type 1 (NT1)  ·  Sponsor: Vertex Pharmaceuticals Incorporated

PhasePhase 1
Planned participants118
Who can joinAll sexes, 18 Years to 55 Years
Healthy volunteersYes

About this study

The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics (PK) of VX-433 following single and multiple ascending doses, as well as to assess the effect of VX-433 on the PK of midazolam, bupropion, and hydroxybupropion.

This description comes directly from the study's public registry record.

Talk to the study team

Medical Information  ·  617-341-6777  ·  medicalinfo@vrtx.com

Always discuss trial participation with your own doctor first.

Locations (1)

ICON - Utah - Salt Lake City OfficeSalt Lake City, Utah, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07584434