Condition: Atrial Fibrillation · Stroke Prevention in Patients With Atrial Fibrillation · Left Atrial Appendage Closure · Sponsor: National Medical Research Center for Therapy and Preventive Medicine
This is a prospective, non-randomized, observational cohort study conducted at the FSBI "NMRC TPM" of the Ministry of Healthcare of the Russian Federation. Left atrial appendage closure (LAAC) has been shown to be non-inferior to oral anticoagulation for preventing cardioembolic events in patients with atrial fibrillation. However, the optimal post-procedural antithrombotic regimen following LAAC remains unclear, with no consensus on evidence-based therapy. Given current trends in cardiology favoring reduced-intensity antithrombotic strategies, this study aims to contribute to the evidence base by evaluating whether LAAC followed by reduced-dose apixaban (2.5 mg BID) for 3 months with subsequent complete withdrawal of antithrombotic therapy is superior to long-term standard-dose DOAC therapy in patients with non-valvular atrial fibrillation.
This description comes directly from the study's public registry record.
Timofey Brontveyn, Medical doctor · +79150579995 · tbrontveyn.md@gmail.com
Karapet Davtyan, Professor · +79037758779 · kdavtyan@gnicpm.ru
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| Federal State Budgetary Institution National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthсare of the Russian Federation | Moscow, Russia | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07575867