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Study identifier: NCT07574593 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

NORM-HF Pivotal Study

Condition: Heart Failure · NYHA Class III Heart Failure · NYHA Class II Heart Failure  ·  Sponsor: Foundry Innovation & Research 1, Limited (FIRE1)

PhaseNA
Planned participants800
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is an international, multi-center, prospective, randomized, open-label blinded endpoint study designed to demonstrate that use of the FIRE1 NORM™ System in the management of New York Heart Association Class II/III HF patients is superior for reducing the combined endpoint of worsening HF events and cardiovascular mortality compared to standard of care treatment. Patients will be randomized in a 1:1 ratio to receive either NORM™ System and guided heart failure management (intervention group) or usual standard of care with guided heart failure management (control group).

This description comes directly from the study's public registry record.

Talk to the study team

Troy Penz  ·  +1 617-802-5911  ·  NORM-HF@fire1foundry.com

Always discuss trial participation with your own doctor first.

Locations (3)

Cardiovascular Institute of San DiegoChula Vista, California, United StatesRecruiting
Saint Francis Health SystemTulsa, Oklahoma, United StatesRecruiting
North Central Heart - Avera HospitalSioux Falls, South Dakota, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07574593