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Study identifier: NCT07573176 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

Condition: Depressive Disorder, Major  ·  Sponsor: Janssen Research & Development, LLC

PhasePhase 3
Planned participants600
Who can joinAll sexes, 18 Years to 74 Years
Healthy volunteersNo

About this study

The main purpose of this study is to assess how well the study drug (JNJ-42847922) works (efficacy) compared with placebo in improving depressive symptoms in participants with major depressive disorder (\[MDD\], a common mood disorder that causes a lasting feeling of sadness and a loss of interest in everyday activities) in double-blind treatment phase. Further, to evaluate long-term safety and tolerability of JNJ-42847922 in participants with MDD in the open label treatment phase.

This description comes directly from the study's public registry record.

Talk to the study team

Study Contact  ·  844-434-4210  ·  Participate-In-This-Study1@its.jnj.com

Always discuss trial participation with your own doctor first.

Locations (16)

CI TrialsBellflower, California, United StatesRecruiting
Excell Research IncOceanside, California, United StatesRecruiting
Sunwise Clinical ResearchWalnut Creek, California, United StatesRecruiting
UHC ResearchDoral, Florida, United StatesRecruiting
Nuovida Research CenterMiami, Florida, United StatesRecruiting
IPTB Clinical ResearchTampa, Florida, United StatesRecruiting
Health Synergy Clinical ResearchWest Palm Beach, Florida, United StatesRecruiting
Accelerated Clinical Research Group LLCSnellville, Georgia, United StatesRecruiting
Adams Clinical BostonBoston, Massachusetts, United StatesRecruiting
Adams Clinical WatertownWatertown, Massachusetts, United StatesRecruiting
CenExel Marlton NJMarlton, New Jersey, United StatesRecruiting
Integrative Clinical Trials LLCBrooklyn, New York, United StatesRecruiting

+ 4 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07573176