Condition: Neck Pain · Migraine · Low Back Pain · Sponsor: Bozok University
Migraine is one of the primary headache disorders with a high prevalence worldwide, leading to significant disability and reduced quality of life. Trigeminal nerve activation and alterations in central pain processing mechanisms play a crucial role in the pathophysiology of migraine. Recent studies suggest that migraine may not only be a headache disorder but also a systemic pain disorder associated with changes in central pain processing mechanisms. Central sensitization is defined as increased sensitivity of nociceptive neurons in the central nervous system to afferent stimuli and is considered a key mechanism in the development and maintenance of chronic pain conditions. This condition is characterized by pain hypersensitivity, allodynia, and generalized pain sensitivity. In addition to headaches, other musculoskeletal pains are also frequently reported in migraine patients. Spinal pain, particularly neck and lower back pain, can occur in migraine sufferers, with central sensitization contributing to the condition, considering the spine as a chain. Large population-based studies have shown a significant association between primary headaches and persistent low back pain, and a higher prevalence of concomitant low back pain has been reported in individuals with chronic migraine and chronic tension-type headaches. This association is suggested to be explained by the shared nociceptive pathways of the head and spinal structures and the changes in central pain processing seen …
This description comes directly from the study's public registry record.
Dilara ONAN, PhD · +905358642234 · dilaraonan@gmail.com
Pelin YENİLMEZ YEŞİLDAŞ, Neurologist · +905392040612 · pelinnyenilmez@gmail.com
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| Gazi University | Gaziantep, Merkez, Turkey (Türkiye) | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07567300