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Study identifier: NCT07566156 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Enfortumab Vedotin in Combination With Pembrolizumab vs. Concurrent Chemoradiotherapy (cCRT) in People With Muscle Invasive Bladder Cancer (EV-309)

Condition: Urothelial Cancer · Urinary Bladder Neoplasms  ·  Sponsor: Astellas Pharma Global Development, Inc.

PhasePhase 3
Planned participants390
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is being done to see how well two drugs (enfortumab vedotin and pembrolizumab) work together as a bladder preservation approach to treat patients with muscle invasive bladder cancer. The study will compare these drugs to concurrent chemoradiotherapy that is usually used to treat this cancer (standard of care). The study will enroll patients with muscle-invasive bladder cancer (MIBC) who have cancer that has not spread outside the bladder.

This description comes directly from the study's public registry record.

Talk to the study team

Pfizer CT.gov Call Center  ·  1-800-718-1021  ·  ClinicalTrials.gov_Inquiries@pfizer.com

Always discuss trial participation with your own doctor first.

Locations (11)

Samsun Clinic - Ridley-Tree Cancer CenterSanta Barbara, California, United StatesRecruiting
Medical Oncology Hematology ConsultantsNewark, Delaware, United StatesRecruiting
Illinois Cancer SpecialistsNiles, Illinois, United StatesRecruiting
Fort Wayne Medical Oncology and HematologyFort Wayne, Indiana, United StatesRecruiting
Missouri Cancer AssociatesColumbia, Missouri, United StatesRecruiting
Williamette Valley Cancer Institute and Research CenterEugene, Oregon, United StatesRecruiting
Compass Oncology - WestTigard, Oregon, United StatesRecruiting
SCRI Oncology PartnersNashville, Tennessee, United StatesRecruiting
Texas OncologyAustin, Texas, United StatesRecruiting
Texas Oncology - Northeast TexasTyler, Texas, United StatesRecruiting
Virginia Oncology AssociatesNorfolk, Virginia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07566156