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Study identifier: NCT07561320 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Mechanochemical Ablation Versus Ultrasound-Guided Foam Sclerotherapy of the Great Saphenous Vein

Condition: Varicose Veins of Leg With Long Saphenous Vein Distribution · Varicose Veins of Lower Limb  ·  Sponsor: Antonio Eduardo Zerati

PhasePhase 4
Planned participants50
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study compares two minimally invasive treatments for varicose veins in the legs, specifically the great saphenous vein. Varicose veins can cause symptoms such as leg pain, swelling, and skin changes. One commonly used treatment is foam sclerotherapy, where a special foam is injected into the vein to close it. This method is simple and allows patients to return quickly to their daily activities, but sometimes the vein can reopen, requiring additional treatments. Another option is mechanochemical ablation, which combines a small device with a medication to close the vein. This method also allows for quick recovery and may have a lower chance of the vein reopening. In this study, 50 patients with varicose veins will be randomly assigned to receive one of these two treatments. Doctors will follow patients over time to evaluate: How well the treated vein stays closed Improvement in quality of life Pain during the procedure Possible complications All procedures are performed with local anesthesia, and additional small varicose veins are treated at the same time.

This description comes directly from the study's public registry record.

Talk to the study team

Antonio Zerati, PhD  ·  +5511996354925  ·  a.zerati@fm.usp.br

Always discuss trial participation with your own doctor first.

Locations (1)

Hospital da Clínicas da FMUSPSão Paulo, São Paulo, BrazilRecruiting

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Source record: clinicaltrials.gov/study/NCT07561320