Condition: Cardiac Amyloidosis · Sponsor: Brigham and Women's Hospital
The primary goal of this pilot study is to determine whether \[64Cu\]FBP8, a novel fibrin-binding positron emission tomography (PET) probe, can identify intracardiac thrombi when paired with simultaneous hybrid cardiac PET/MRI in twenty (20) individuals with transthyretin or light chain cardiac amyloidosis and atrial fibrillation (AF) or atrial flutter (AF). The primary hypothesis of this study is that \[64Cu\]FBP8 PET/MRI can identify intracardiac thrombi in \>90% of subjects with confirmed intracardiac thrombi based on transesophageal echocardiogram (TEE). In secondary analyses, the investigators will seek to determine associations between intracardiac thrombi and left atrial function and left ventricular amyloid burden.
This description comes directly from the study's public registry record.
Vicente Morales Oyarvide, MD, MPH · 6172335860 · vmorales-oyarvide@bwh.harvard.edu
Sharmila Dorbala, MD, MPH · 617-732-6290 · sdorbala@bwh.harvard.edu
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| Brigham and Women's Hospital | Boston, Massachusetts, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07560306