Condition: Post-Mastectomy Chronic Pain Syndrome · Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
Chronic post-surgical pain is a common complication following mastectomy and represents a significant source of long-term morbidity. Pain that persists beyond the expected period of tissue healing can interfere with physical functioning, psychological well-being, and quality of life. Despite advances in surgical and anesthetic techniques, the mechanisms contributing to chronic postmastectomy pain remain incompletely understood. Dexamethasone is a corticosteroid routinely administered in the perioperative setting for the prevention of postoperative nausea and vomiting. In addition to its antiemetic properties, dexamethasone has potent anti-inflammatory and immunomodulatory effects that may influence tissue healing and pain processing pathways. Given its widespread use during surgery, understanding its potential impact on long-term pain outcomes is clinically relevant. Clinical observational studies examining the association between perioperative dexamethasone administration and chronic postmastectomy pain have not demonstrated a clear or consistent relationship. However, by design, observational studies cannot establish causality or definitively exclude a potential effect of perioperative dexamethasone on the development of chronic post-surgical pain. In contrast, preclinical studies using animal models of post-surgical pain have shown that perioperative exposure to dexamethasone may be associated with increased postoperative pain sensitivity and hyperalgesia. These finding…
This description comes directly from the study's public registry record.
Oana Predescu, MD, PhD, MSc · 514-934-1934 · oana.predescu@mcgill.ca
Anne-Françoise Rousseau, MD, PhD · 514-934-1934 · anne-francoise.rousseau@mcgill.ca
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| McGill University Health Centre (MUHC) | Montreal, Quebec, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07556952