Condition: Carotid Artery Stenosis Symptomatic · Ischemic Cerebral Infarction · Stroke Ischemic · Sponsor: Maastricht University Medical Center
Narrowing of the carotid artery due to atherosclerosis with an unstable plaque can cause a stroke. Patients with carotid artery disease who have had a TIA or minor stroke and are at high risk of another stroke are often treated with surgery or stenting to remove the plaque. For lower-risk patients, medication alone is the better option, as surgery also carries risks. A new decision method, based on MRI detection of unstable plaques (IMPROVE), can better assess stroke risk and help determine which patients do or do not need surgery. We are investigating whether this method is at least as effective as the standard approach, which mainly considers the degree of narrowing. We expect that this new method will help reduce strokes and lower healthcare costs. Patients will be followed for several years to compare which method is better for health and costs.
This description comes directly from the study's public registry record.
M. Eline Kooi, Prof. dr. · +31 43 387 4911 · improve.trial@mumc.nl
Robin M.M. Pleumeekers, MSc. · +31 43 387 7622 · robin.pleumeekers@mumc.nl
Always discuss trial participation with your own doctor first.
| Rijnstate | Arnhem, Gelderland, Netherlands | Not Yet Recruiting |
| Radboud UMC | Nijmegen, Gelderland, Netherlands | Not Yet Recruiting |
| Zuyderland | Heerlen, Limburg, Netherlands | Not Yet Recruiting |
| Maastricht University | Maastricht, Limburg, Netherlands | Recruiting |
| Amsterdam UMC | Amsterdam, North Holland, Netherlands | Not Yet Recruiting |
| Isala | Zwolle, Overijssel, Netherlands | Not Yet Recruiting |
| Albert Schweitzer Ziekenhuis | Dordrecht, South Holland, Netherlands | Not Yet Recruiting |
| Erasmus MC | Rotterdam, South Holland, Netherlands | Not Yet Recruiting |
| Haaglanden MC | The Hague, South Holland, Netherlands | Not Yet Recruiting |
| Utrecht UMC | Utrecht, Utrecht, Netherlands | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07556887