Condition: Diabete Type 2 · Cardio Vascular Disease · Sponsor: Weill Cornell Medical College in Qatar
This study aims to isolate endothelial progenitor cells (EPCs) from participants with type 2 diabetes (T2D) and cardiovascular complications and to comprehensively characterize EPC dysfunction. Specifically, the study will evaluate maladaptive angiocrine signaling, calcium signaling pathways, and the role of inflammation in EPC function and the progression of atherosclerosis during T2D development. A sub-study will assess EPC functionality by examining endothelial nitric oxide synthase (eNOS) expression and activity, as well as the effectiveness of in vitro eNOS gene enhancement.
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| Hamad Medical Corporation | Doha, Qatar | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07556497