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Study identifier: NCT07555431 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Dolutegravir Versus Dolutegravir in Combination With Tenofovir for the Treatment of HTLV-1 Infection

Condition: HTLV-1 Infection · HTLV I Associated Myelopathies · HTLV I Associated T Cell Leukemia Lymphoma  ·  Sponsor: Carlos Brites

PhasePhase 2
Planned participants146
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This phase 2b, open-label, randomized controlled trial evaluates the efficacy and safety of dolutegravir (DTG) alone versus dolutegravir combined with tenofovir disoproxil fumarate (TDF) in individuals with HTLV-1 infection and associated clinical manifestations. The primary objective is to compare changes in HTLV-1 proviral load at 24 and 48 weeks. Secondary outcomes include clinical, functional, immunological, and quality-of-life measures.

This description comes directly from the study's public registry record.

Talk to the study team

Carlos Brites, MD, PhD  ·  +5571992329552  ·  crbrites@gmail.com

Estela Luz  ·  +5571999867515  ·  eluz5@yahoo.com.br

Always discuss trial participation with your own doctor first.

Locations (1)

Hospital Universitário Professor Edgard SantosSalvador, Estado de Bahia, BrazilRecruiting

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Source record: clinicaltrials.gov/study/NCT07555431