Condition: Rectal Adenocarcinoma · High-Risk Cancer · MSS · Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University
To explore the efficacy and safety of an intensified treatment regimen consisting of short-course radiotherapy followed by mFOLFOX6 chemotherapy combined with precise targeted therapy (based on RAS/BRAF status: cetuximab for wild-type, bevacizumab for mutant) and a PD-1 monoclonal antibody, compared with short-course radiotherapy followed by mFOLFOX6 chemotherapy alone, in high-risk locally advanced pMMR/MSS rectal adenocarcinoma through a prospective, randomized controlled phase III clinical study, providing high-level evidence-based medical evidence to establish a superior neoadjuvant treatment strategy for this population.
This description comes directly from the study's public registry record.
Jun Huang, PhD. · +8613926451242 · huangj97@mail.sysu.edu.cn
Fang He, MD. · +8618826059789 · hefang23@mail.sysu.edu.cn
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| Sixth Affiliated Hospital, Sun Yat-sen University | Guangzhou, Guangdong, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07549399