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Study identifier: NCT07548385 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN

Condition: Total Knee Replacement Surgery · Post-operative Pain  ·  Sponsor: Icahn School of Medicine at Mount Sinai

PhasePhase 3
Planned participants235
Who can joinAll sexes, 18 Years to 85 Years
Healthy volunteersNo

About this study

This is a prospective, randomized study. The purpose of this study is to evaluate if the addition of Suzetrigine, a new pain medication, to well established peri-operative pain regimen used for total knee replacement surgery will effect pain control. 1. Does Suzetrigine given pre-operatively decrease the total opioid consumed after total knee replacement surgery? 2. Dose Suzetrigine given pre-operatively decrease the visual analog pain scale pain scores after total knee replacement surgery? Study participants will be randomly assigned to receive either Suzetrigine medication or placebo medication.

This description comes directly from the study's public registry record.

Talk to the study team

Michael Lazar, MD  ·  212-523-2500  ·  michael.lazar@mountsinai.org

Himani Bhatt, DO  ·  212-523-2500  ·  himani.bhatt@mountsinai.org

Always discuss trial participation with your own doctor first.

Locations (1)

Mount Sinai WestNew York, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07548385