Condition: HER2-negative · Gastroesophageal Junction · Esophageal Adenocarcinoma · Sponsor: Gilead Sciences
The goal of this clinical study is to learn more about the study drug, Denikitug (DEN, GS-1811), to evaluate the efficacy and safety of Denikitug Monotherapy and Denikitug-based combinations in in participants with human epidermal growth factor receptor 2 (HER2)-Negative, unresectable, recurrent, and/or metastatic, gastroesophageal junction (GEJ), and esophageal adenocarcinomas. The primary objective of this study is to assess the effect of DEN as a monotherapy or in combination with nivolumab (NIVO) or ramucirumab (RAM) and paclitaxel (PAC) on objective response rate (ORR) as assessed by the investigator according to Response Evaluation Criteria in Solid Tumors (RECIST Version1.1).
This description comes directly from the study's public registry record.
Gilead Clinical Study Information Center · 1-833-445-3230 (GILEAD-0) · GileadClinicalTrials@gilead.com
Always discuss trial participation with your own doctor first.
| Massachusetts General Hospital | Boston, Massachusetts, United States | Recruiting |
| Chris O'Brien Lifehouse | Camperdown, New South Wales, Australia | Recruiting |
| Royal Brisbane and Women's Hospital | Herston, Queensland, Australia | Recruiting |
| Hollywood Private Hospital | Nedlands, Western Australia, Australia | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07546812