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Study identifier: NCT07546591 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Pilot Study to Evaluate the Ability of Lactoferrin to Modulate Iron Homeostasis and Exercise Performance in Exercising Females

Condition: Iron Deficiencies · Low Ferritin · Iron Deficiency  ·  Sponsor: Lindenwood University

PhaseNA
Planned participants30
Who can joinFemale, 18 Years to 45 Years
Healthy volunteersYes

About this study

This randomized, double-blind, active-controlled trial will evaluate the effects of human lactoferrin supplementation combined with low-dose iron on iron status, aerobic performance, and lactate metabolism in exercising women with low ferritin. Approximately 30 healthy, menstruating women aged 18-45 years with serum ferritin \<35 µg/L will be enrolled in an 8-week intervention. Participants will be stratified by baseline ferritin status and randomized to receive 100 mg lactoferrin + 5 mg iron, 300 mg lactoferrin + 5 mg iron, or placebo + 5 mg iron daily. Primary outcomes include changes in ferritin and hematological parameters. Secondary outcomes include VO₂peak, time to exhaustion, and blood lactate responses during standardized treadmill testing. This study will determine whether lactoferrin enhances iron homeostasis and improves physiological and performance outcomes in exercising women with low iron stores.

This description comes directly from the study's public registry record.

Talk to the study team

Anthony M Hagele, MS  ·  6369494785  ·  ahagele@lindenwood.edu

Joesi M Morey, MS  ·  jmorey@lindenwood.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Exercise and Performance Nutrition LaboratorySaint Charles, Missouri, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07546591