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Study identifier: NCT07545759 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Diarrhea (IBS-D)

Condition: Irritable Bowel Syndrome · Diarrhea  ·  Sponsor: Eli Lilly and Company

PhasePhase 2
Planned participants531
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

The purpose of this study is to evaluate how well brenipatide (LY3537031) is tolerated, what side effects may occur, and the safety and efficacy in participants with Irritable Bowel Syndrome-Diarrhea (IBS-D). The study drug will be administered subcutaneously (SC) (under the skin) when compared with placebo. The study will last approximately 35 weeks.

This description comes directly from the study's public registry record.

Talk to the study team

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or  ·  1-317-615-4559  ·  LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact  ·  clinical_inquiry_hub@lilly.com

Always discuss trial participation with your own doctor first.

Locations (89)

Del Sol Research Management - MesaMesa, Arizona, United StatesRecruiting
Smart Cures Clinical ResearchAnaheim, California, United StatesRecruiting
Om Research LLCLancaster, California, United StatesRecruiting
United Medical Doctors - Los AlamitosLos Alamitos, California, United StatesRecruiting
Encore Medical ResearchHollywood, Florida, United StatesRecruiting
Clinical Research of OsceolaKissimmee, Florida, United StatesRecruiting
Springfield Clinic - FirstSpringfield, Illinois, United StatesRecruiting
Gastroenterology Health PartnersNew Albany, Indiana, United StatesRecruiting
Gastroenterology Health PartnersLouisville, Kentucky, United StatesRecruiting
Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research CenterWyoming, Michigan, United StatesRecruiting
Mayo Clinic in Rochester, MinnesotaRochester, Minnesota, United StatesNot Yet Recruiting
Ohio GastroenterologyColumbus, Ohio, United StatesRecruiting

+ 77 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07545759