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Study identifier: NCT07543744 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Comparative Study of Pharmacokinetics, Safety, and Immunogenicity of RPH-030 and Vectibix® in Patients With Metastatic Colorectal Cancer With Wild-type RAS as First-line Therapy in Combination With FOLFIRI

Condition: Metastatic Colorectal Cancer  ·  Sponsor: R-Pharm

PhasePhase 1
Planned participants180
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The primary objective of this study is to demonstrate equivalence of pharmacokinetic properties, and comparability of safety and immunogenicity parameters of RPH-030 and Vectibix® following a single (first) intravenous administration to patients with mCRC with wild-type RAS genes as 1-line therapy in combination with FOLFIRI. The additional objective is to perform a pilot evaluation of the efficacy of RPH-030 and Vectibix® following a single (first) intravenous administration to patients with mCRC with wild-type RAS genes as 1-line therapy in combination with FOLFIRI.

This description comes directly from the study's public registry record.

Talk to the study team

Andrey Osherov  ·  +79690189217  ·  osherov@rpharm.ru

Always discuss trial participation with your own doctor first.

Locations (26)

State Budgetary Healthcare Institution of the Arkhangelsk Region "Arkhangelsk Oncology Dispensary"Arkhangelsk, RussiaRecruiting
Moscow City Oncology Hospital No. 62 (MGOB 62)Istra, RussiaRecruiting
Regional Budgetary Healthcare Institution "Ivanovo Regional Oncology Dispensary"Ivanovo, RussiaRecruiting
State Budgetary Healthcare Institution of Kaluga Region "Kaluga Regional Clinical Oncology Dispensary"Kaluga, RussiaRecruiting
State Autonomous Healthcare Institution "Republican Clinical Oncology Dispensary of the Ministry of Health of the Republic of Tatarstan named after Professor M.Z. Sigal"Kazan', RussiaRecruiting
State Budgetary Healthcare Institution "Kuzbass Clinical Oncology Dispensary named after M.S. Rappoport" (SBHI "KCOD")Kemerovo, RussiaRecruiting
State Budgetary Healthcare Organisation "Clinical Oncology Dispensary No. 1" under the Ministry of Healthcare of Krasnodar regionKrasnodar, RussiaRecruiting
Regional Budgetary Healthcare Institution "Kursk Oncology Research and Clinical Center named after G.E. Ostroverkhov"Kursk, RussiaRecruiting
State Budgetary Healthcare Institution "Leningrad Regional Clinical Hospital"Kuz'molovskiy, RussiaRecruiting
The Loginov Moscow Clinical Scientific Center (MCSC)Moscow, RussiaRecruiting
N.N. Blokhin National Medical Research Center of Oncology (Blokhin NRC of Oncology)Moscow, RussiaRecruiting
Oncology Center No. 1 of the City Clinical Hospital named after S.S. Yudin of the Moscow Healthcare DepartmentMoscow, RussiaRecruiting

+ 14 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07543744