Condition: Tri-specific Killer Engager · Solid Tumor · Advanced Solid Tumor · Sponsor: Masonic Cancer Center, University of Minnesota
This is a first-in-human Phase 1a/1b trial of a B7-H3-targeted natural killer (NK) cell engager, referred to as a TriSpecific Killer Engager (TriKE), for the treatment of select solid tumor cancers. To be considered for the study, a patient must be 18 years or older, have histologically or cytologically confirmed advanced/metastatic cancer that, based on literature reports, expresses B7-H3 at a high frequency, measurable disease by RECIST 1.1 (exception: mCRPC limited to bone metastasis are exempt from this requirement), meets the disease specific criteria for prior failed therapy, and refractory to, intolerant of, or ineligible for therapy options that are known to provide clinical benefit for their diagnosis.
This description comes directly from the study's public registry record.
Nicholas Zorko, MD · 612-625-3051 · zorko004@umn.edu
Always discuss trial participation with your own doctor first.
| Masonic Cancer Center at University of Minnesota | Minneapolis, Minnesota, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07541573