Condition: Major Depressive Disorder (MDD) · Probiotic Intervention · Sponsor: First Affiliated Hospital of Chongqing Medical University
The goal of this clinical trial is to evaluate the efficacy and safety of sertraline combined with Lactobacillus crispatus in adolescents aged 12-18 years with major depressive disorder. The main question it aims to answer is: Whether sertraline combined with Lactobacillus crispatus is superior to sertraline combined with placebo in reducing depressive symptoms and improving emotional symptoms in adolescents with depression. If there is a comparison group: Researchers will compare sertraline combined with Lactobacillus crispatus with sertraline combined with placebo ( look-alike substance that contains no probiotics) to determine whether the addition of Lactobacillus crispatus provides greater therapeutic benefit in adolescents with depression. Participants will: 1. Receive sertraline combined with Lactobacillus crispatus or sertraline combined with placebo for 8 weeks; 2. Attend clinic visits every 4 weeks for clinical assessments and safety monitoring
This description comes directly from the study's public registry record.
Teng Teng · +86 18883368354 · tengteng@hospital.cqmu.edu.cn
Always discuss trial participation with your own doctor first.
| The Affiliated Dazu's Hospital of Chongqing Medical University | Longgang, Chongqing Municipality, China | Not Yet Recruiting |
| The Affiliated Hospital of Chongqing Medical University | Chongqing, Yuzhong, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07539805