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Study identifier: NCT07537348 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Safety and Efficacy of Leucine-Restricted Diet Combined With Chemotherapy and Immunotherapy in Advanced Gastric Cancer

Condition: Advanced Gastric Cancer  ·  Sponsor: Qilu Hospital of Shandong University

PhasePhase 2
Planned participants73
Who can joinAll sexes, 18 Years to 70 Years
Healthy volunteersNo

About this study

Based on existing literature, we posit that a leucine-restricted diet is safe and well-tolerated in patients with advanced gastric cancer receiving combined chemotherapy and immunotherapy. Patients adhering to this dietary regimen exhibit a significant reduction in serum leucine concentrations, with no notable impact on the serum levels of other amino acids. Furthermore, leucine restriction promotes the activation of immune cells within the tumor microenvironment. When applied in conjunction with chemotherapy and immunotherapy for advanced gastric cancer, this approach demonstrates synergistic anti-tumor efficacy. It is expected to enhance tumor response rates , improve the 1-year survival rate, prolong overall survival (OS), and ultimately optimize patient prognosis.

This description comes directly from the study's public registry record.

Talk to the study team

Hui Qu, Doctor of Medicine  ·  +86-18560085120  ·  doctorquhui@email.sdu.edu.cn

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Locations (1)

Qilu Hospital of Shandong UniversityJinan, Shandong, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT07537348