Condition: Chronic Limb-Threatening Ischemia · Sponsor: Shin Kong Wu Ho-Su Memorial Hospital
Chronic limb-threatening ischemia (CLTI) is the most severe form of peripheral artery disease, a condition in which narrowed or blocked arteries reduce blood flow to the legs. People with CLTI may have severe leg pain at rest, non-healing wounds, or gangrene, and face a high risk of leg amputation and death. Even after successful procedures to restore blood flow to the leg (called revascularization), many patients still experience serious complications. Inflammation in the blood vessels is believed to play an important role in these poor outcomes. Colchicine is an anti-inflammatory medication that has been used safely for decades to treat gout and other inflammatory conditions. Recent large clinical trials have shown that a low dose of colchicine (0.5 mg per day) can reduce heart attacks and strokes in patients with coronary artery disease. However, it has not been studied in patients with CLTI. The CIRCLE-Asia trial (Colchicine in Chronic Limb-Threatening Ischemia for Reduction of Complications and Limb Events in Asia) is a pilot study designed to evaluate whether colchicine can improve outcomes in patients with CLTI who have recently undergone a successful procedure to restore blood flow to their leg. Treatment begins within 7 days of the procedure. This is a randomized, double-blind, placebo-controlled, multicenter trial conducted at five hospitals in Taiwan. A total of 200 adult patients with CLTI who have undergone successful revascularization will be randomly assigne…
This description comes directly from the study's public registry record.
Donna SH Lin, MD · +886-2-2833-2211 · donna.lin24@gmail.com
Always discuss trial participation with your own doctor first.
| Shin Kong Wu Ho-Su Memorial Hospital | Taipei, Taipei, Taiwan | Recruiting |
| Chi Mei Medical Center | Tainan, Taiwan | Not Yet Recruiting |
| National Taiwan University Hospital | Taipei, Taiwan | Recruiting |
| Taipei Veterans General Hospital | Taipei, Taiwan | Not Yet Recruiting |
| Linkou Chang Gung Memorial Hospital | Taoyuan, Taiwan | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07536373