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Study identifier: NCT07536113 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Assessing the Efficacy and Safety of ctDNA-driven Selection for Anti-EGFR Retreatment in a Real World Metastatic Colorectal Cancer Patients Cohort (the REalCHALLENGE Study)

Condition: Metastatic Colorectal Cancer (CRC)  ·  Sponsor: Niguarda Hospital

PhaseN/A
Planned participants250
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is an observational, retrospective, international and multicenter study funded by Fondazione Oncologia Niguarda ETS to assess the efficacy of anti-EGFR rechallenge regimens in the largest real-world cohort of MSS mCRC patients screened for RAS/BRAF/PIK3CA ctDNA status on liquid biopsy within the MEN1611-02 C-PRECISE-01 trial. The study will collect molecular, clinical and outcome data of patients already available at participating centers.

This description comes directly from the study's public registry record.

Talk to the study team

Salvatore Siena, MD  ·  +39026444  ·  salvatore.siena@ospedaleniguarda.it

Always discuss trial participation with your own doctor first.

Locations (1)

ASST GOM NiguardaMilan, Italia, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT07536113